Neuropathies are characterized by a progressive loss of nerve fibers
Noninvasive Testing
- Nerve conduction studies and Electromyography- A test commonly used to evaluate the function and the ability of electrical conduction of the motor and sensory nerves.
- Quantitative sensory testing
- Autonomic Function Tests
- Monofilament testing - If the patient does not feel the wire at 4 or more at 10 testing sites- the test is positive for neuropathy
Pathophysiology of Diabetic Peripheral Neuropathy
Result from vascular disease:
- Endothelial dysfunction
- Deficiency of myoinositol-altering myelin synthesis
- Chronic hyperosmolarity-causing edema of nerve trunks
- Increased sorbitol and fructose
Diabetic Neuropathy can contribute to Structural foot deformities
The symptoms of peripheral neuropathy include the following
- Hyperesthesia-Is a condition that involves an abnormal increase in sensitivity to stimuli of the senses.
- Paresthesia- Is a sensation of tingling, pricking, or numbness of a person's skin. It is more generally known as the feeling of "pins and needles".
- Dysesthesia-It is defined as an unpleasant, abnormal sense of touch, and it may or may not be, considered as a kind of pain.
- Radicular pain-Is pain "radiated" along the dermatome (sensory distribution) of a nerve due to inflammation or other irritation
- Anhydrosis-Means lack of sweating.
Peripheral Neuropathy Signs
- Loss of sensation in the foot- Results in repetitive stress
- Injuries and fractures
- Loss of vibratory and position sense
- Loss of deep tendon reflexes
- Trophic ulceration
- Foot drop
Treatment
Diet
- Patients with diabetic neuropathy should develop a realistic diet for lowering blood glucose. This should be guided by a nutritionist or doctor
Medicines widely used to help with painful symptoms
- Selective serotonin and norepinephrine reuptake inhibitors- example:Duloxetine (Cymbalta)
- Tricyclic antidepressants- example: Amitriptyline (Elavil)
- Anticonvulsants- example:Gabapentin (Neurontin)
- Pregabalin (Lyrica)- FDA approved for neuropathic pain associated with diabetic peripheral neuropathy or postherpetic neuralgia.
- Capsaicin cream (Capsacin)- A natural chemical derived from plants of Solanaceae. This is a topical medicine and is the active component of chili peppers.
- Neuremedy (Benfotiamine)- For the nutritional management of peripheral neuropathy.